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Covers the major ApoE polymorphisms rs429358 and rs7412..
ApoE
ApoE Genetic Testing
ApoE genotyping assay for the analysis of genetic variants associated with Alzheimer's disease and cardiovascular health. Designed for efficient sample processing and reliable genotype determination.
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Direct amplification from oral swab samples.
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Automated analysis using standard real-time PCR instruments.
Product Overview
ApoE genotyping provides genetic insights related to lipid metabolism, cardiovascular health, and Alzheimer's disease (AD) risk, supporting personalized health management and research applications.
- Involved in lipid transport and metabolism
- Associated with cardiovascular and metabolic health
- May influence individual responses to statin therapy
- Supports research in precision health and lipid metabolism
- Certain genotypes are linked to increased AD risk
Key ApoE SNPs
Covers ApoE rs429358 and rs7412 genotyping.
qPCR-Based Analysis
Dual-channel fluorescent probe assay for accurate genotype determination.
Direct Oral Swab Testing
Extraction-free workflow with direct amplification from oral swab samples.
Research Ready
Supports cardiovascular and Alzheimer's disease (AD) research applications.
Apolipoprotein | ApoE4 | ApoE3 | ApoE2 |
|---|---|---|---|
Negative | ε4/ε4, ε3/ε4 | ε2/ε4, ε3/ε3 | ε2/ε3, ε2/ε2 |
Population proportion | 10%-15% | 70%-80% | 5%-10% |
Atorvastatin | Low response | Responsive | Responsive |
Pravastatin | Low response | Responsive | Responsive |
Lovastatin | Low response | Responsive | Responsive |
Rosuvastatin | Low response | Responsive | Responsive |
Fluvastatin | Low response | Responsive | Responsive |
Simvastatin | Responsive | Responsive | Low response |
Probucol | Responsive | Responsive | Low response |
Alzheimer's disease | Higher risk | Normal | Lower risk |
Reference: Expert consensus on SLCO1B1 and ApoE polymorphism testing and clinical application of statins. Chinese Journal of Laboratory Medicine, 2023, 46(7):672-680.
1-on-1 Expert Support
Get personalized guidance from our technical experts to help solve complex research challenges, so you can stay focused on your science.
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